Application of bioinformatics to optimization of serum proteome in oral leukoplakia and oral squamous cell carcinoma
نویسندگان
چکیده
منابع مشابه
Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma.
Intermediate filaments are involved in cell migration and intracellular signal transduction pathways. In a variety of organs, the expression of distinct intermediary filaments are further associated with distinct steps of malignant transformation. In this study, we seeked to define the cytokeratin (Ck) expression pattern in oral leukoplakia and oral squamous cell carcinoma (OSCC). One hundred a...
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OBJECTIVES Oral leukoplakia (OL) is the main potentially malignant disorder and oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral mucosa. Stromal myofibroblasts play an important role in tumor invasion and metastasis, due to its ability to modify the extracellular matrix. This study aimed to evaluate the presence of stromal myofibroblasts in OL and OSCC. Differences ...
متن کاملSerum Endostatin Levels in Oral Squamous Cell Carcinoma
Introduction: Endostatin is a C-terminal proteolytic fragment of collagen XVIII and, as with angiostatin and thrombospondin, is known as an antiangiogenic agent. The aim of this study was to assess the level of serum endostatin in patients with oral squamous cell carcinoma (SCC), and its association with the clinicopathological characteristics of the tumor. Materials and Methods: Using an ...
متن کاملSerum Glutathione Levels in Oral Leukoplakia and Oral Squamous Cell Carcinoma- A Clinicopathological Study
Oral cancer accounts for the majority of the cancer in South East Asian region and especially in the Indian subcontinent. If diagnosed at an early stage the disease is reported to have a better prognosis. Recently studies have been conducted to determine the levels of serum antioxidants for risk assessment of oral cancer. The aim of this study was to estimate the levels of glutathione in serum ...
متن کاملDetection of Apoptosis in Leukoplakia and Oral Squamous Cell Carcinoma using Methyl Green Pyronin and Hematoxylin and Eosin
Background & Objective: Cell population and turnover are controlled by a balance between cell proliferation and apoptosis. Detection of apoptosis in oral cancer contributes to its better prognosis and improved management. This study aimed to quantify apoptotic cells in leukoplakia and oral squamous cell carcinoma (OSCC) using methyl green-pyronin (MGP) and hematoxylin and eosin...
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ژورنال
عنوان ژورنال: African Journal of Biotechnology
سال: 2014
ISSN: 1684-5315
DOI: 10.5897/ajb2013.13473